This modest reduction of p19 levels observed in ATLL PBMCs was highly similar to the IFN-α-induced reduction observed in MT-2 cells (Figure 2D) and to recent findings in larger cohorts of HTLV-1-infected individuals [55] as well as ATL patients (Khouri et al., unpublished). The gene discussed is IFNA1; the disease is adult T-cell leukemia/lymphoma.