As CXCR7/CXCL12-mediated ERK1/2 activation was detected in various models [22], [23], [45], [46], we next assessed ERK1/2 cascade activation in NB transduced cells, in response to either CXCL12 or CXCL11 ligand. This evidence concerns the gene CXCL12 and neuroblastoma.