As we showed herein that CXCR7 enabled NB growth reduction in a heterotypic mouse model (Figure 5A), and altered CXCR4/CXCL12-mediated NB migration (Figure 4B), we further evaluated the extent to which CXCR7 would affect both the in vivo CXCR4-mediated growth promoting effect and NB dissemination in a orthotopic environment. The gene discussed is CXCL12; the disease is neuroblastoma.