Interestingly, the volume of NB8×4×7 cell-derived tumors was significantly reduced as compared to that of the NB8×4 group at week 5 (p<0.05), suggesting that CXCR7 significantly affected tumor take of tumors derived from CXCR4-positive NB8×4×7 cells. The gene discussed is CXCR4; the disease is neoplasm.