In the motor neurons of patients with sporadic ALS, the A-to-I conversion at the GluA2 Q/R site is inefficient, and approximately half of the motor neurons express the Q/R site-unedited GluA2 in the majority of ALS cases, rendering the expression of unedited GluA2 as another disease-specific molecular abnormality of sporadic ALS [5], [6]. This evidence concerns the gene GRIA2 and amyotrophic lateral sclerosis.