TCF7L2 and cancer: However, the TCF7L2 pathway has also been involved in several other biological processes, like the differentiation of adipocytes and the regulation of adipokines, among others [16], [33], and the presence of the minor allele of rs7903146 gene variation has been linked to other diseases apart from diabetes, such as the incidence of cancer [36], or the severity of coronary disease [37].