CREB1 and pancreatic neoplasm: Recent investigations in pancreatic cancer xenografts from cell lines BxPC-3 and Panc-1 in mice exposed to social stress have further revealed significant stress-induced growth stimulation of the xenografts associated with the activation of multiple signaling proteins, including ERK, CREB, Src, and AKT [18], most of which are overexpressed in pancreatic cancer [19]–[21].