Mice lacking Pallidin do not properly form melanosomes and platelet dense granules [46], [47] and disruption of human pallidin causes Hermansky-Pudlak Syndrome Type 9, which is characterized by defects in LRO biogenesis and results in severe albinism and excessive bleeding [8]. Here, BLOC1S6 is linked to Hermansky-Pudlak syndrome type 9.