TGFB1 and Bloom syndrome: Both siRNA and nkRNA significantly suppressed collagen deposition in the lungs compared to untreated mice as demonstrated by the significant decrease in fibrosis score and hydroxyproline content of the lungs in BLM/TGF-β1 siRNA and BLM/TGF-β1 nkRNA groups compared to BLM/vehicle and BLM/control RNA groups (Figure 11A, B).