Histological examination of rapamycin- and vehicle-treated uteri and oviducts showed suppression of endometrial carcinogenesis (Figure 6F and 6G) and inhibition of cyst formation (Figure S5A), respectively, with rapamycin treatment confirming the involvement of mTORC1 in the pathogenesis of the Lkb1 mutant phenotype. Here, STK11 is linked to cyst.