TSC2 and endometrial cancer: In this report we have shown that conditional deletion of Lkb1, Tsc1, and Tsc2 in the mesenchymal cells leads to the development of oviductal and uterine pathologies such as endometrial cancer, indicating that dysregulated mTORC1 signaling downstream of LKB1 signaling plays an important role in pathogenesis of the observed defects (Summarized in Table S1).