Among the most relevant functions of the 21 toxicity modulators, we found ribosomal proteins (P0, L8, L10 and RPSA) [35], well known regulators of translation and/or transcription (EIF2G, Pum1 or MED15) [36]–[38], proteins involved in mRNA splicing (Sm-D2 and SmB), vesicle trafficking (Ran, Vps4B, αSNAP and ATP6V1E), protein degradation (PSMD7 and PSMB6), protein folding (DNAJB4 and AFG3L2) and ATP metabolism (ATP5F1) (Table S4), confirming earlier reports that these cellular processes influence the toxicity of polyQ disease proteins [18], [24]. Here, RAN is linked to glycogen storage disease VI.