SNCA and Parkinson disease: Notably, the gene SSA3 is among the most strongly upregulated in the relocation strains, which encodes an HSP70 chaperone protein involved in co-translational protein-membrane targeting and whose overexpression protects a yeast model of Parkinson's disease from alpha-synuclein toxicity [31]; it is therefore possible that this protein helps to prevent toxic aggregation of the PaAtp9 proteins.