Moreover, Ccr1 deficiency decreased kidney injury in models of Alport disease, focal segmental glomerulosclerosis, unilateral ureteral obstruction and toxic nephropathy; however, the attenuated tissue damage was associated with decreased infiltration of lymphocytes and macrophages but not neutrophils in the kidney [38]–[42]. This evidence concerns the gene CCR1 and focal segmental glomerulosclerosis.