Upon infection with EMCV, NLRP3 was redistributed to the perinuclear region or cytoplasmic granular structures, which is also observed in cells stimulated with other NLRP3 ligands such as monosodium urate (MSU), alum or nigericin (Figure 3D)[22] and considered as a hallmark of NLRP3 activation. The gene discussed is NLRP3; the disease is infection.