Expression of CCR5 and CXCR4 on CD4+ iNKTs [43], [45], [59] makes them susceptible to infection with R5-tropic, X4-tropic, and primary isolate viruses [43], [45], [59], resulting in the preferential depletion of CD4+ iNKT cells during in vitro infection [45]. The gene discussed is CD4; the disease is infection.