TP53 and neoplasm: Additional p53 alleles increase tumour resistance and lifespan (Matheu et al, 2007) whereas chronically elevated levels of activated p53 lead to early onset aging (Cao et al, 2003; Maier et al, 2004; Tyner et al, 2002; Varela et al, 2005; Vogel et al, 1999).