CRP and Insulin resistance: In 1988 Gerald Reaven attributed the irregularities associated with the metabolic syndrome to insulin resistance.6 Abdominal fat functions as an endocrine organ that secretes pro-inflammatory adipokines, which could be the underlying pathophysiology for insulin resistance.7 C-reactive protein (CRP) is a marker of subclinical inflammation and a predictor of coronary incidents.8 Furthermore, central obesity leads to an increase in CRP.