However, no correlation could be found between matrix metalloproteinase (MMP)-1, the tissue inhibitor of MMP-1 (TIMMP-1), PWV and blood pressure in patients who received perindopril for six months.15 A more recent study showed that ET-1 contributed to a decreased arterial compliance in hypertension through inhibition of collagen degradation.13 Furthermore, it has been shown that captopril therapy in congestive heart failure decreased endothelin production.12 Here, MMP1 is linked to Hypertension.