For example, the first version of the Acute Myocardial Infarction (AMI) bundle, published in 2005, included the following practices: early administration of aspirin; aspirin at discharge; beta-blocker at discharge; timely initiation of reperfusion (thrombolysis or percutaneous intervention); ACE-inhibitor or angiotensin receptor blockers at discharge for patients with systolic dysfunction; and smoking cessation counseling/nicotine replacement/serotonin uptake inhibitor/referral to cardiac rehabilitation program. This evidence concerns the gene ACE and acute myocardial infarction.