Yet, the sense of this perturbation in IL-18 system, characterized by elevated levels of IL-18BP here described for the first time in the context of schizophrenia, should be deciphered on a time-dependent basis, in the light of its ability to limit harmful inflammation on the one hand and to contribute to increased susceptibility to infection and immune-related diseases, on the other hand [27]. This evidence concerns the gene IL18 and infection.