P28GANK is over-expressed in human HCC, ESCC: esophageal squamous cell carcinoma and colorectal cancer and promotes cell-cycle progression [13-15], which is also associated with multi-drug resistance in gastric cancer and HCC cells [18,19], indicating that p28GANK might be a critical oncogene. The gene discussed is PSMD10; the disease is esophageal squamous cell carcinoma.