The upregulation of p28GANK expression correlated with poor clinical outcomes in human esophageal squamous cell carcinoma [13], colorectal cancer [14], pancreatic cancer [15] and lung cancer [16], indicating that p28GANK is an important oncoprotein involved in the carcinogenesis of various human cancers. The gene discussed is PSMD10; the disease is familial pancreatic carcinoma.