Furthermore, there are suggestions that Foxp3 may not always be a desirable target in every cancer setting because Foxp3+ T cell infiltration does not always predict poor prognosis, for example in colorectal cancer, and because Foxp3 appears to act as a tumor suppressor gene when expressed in non-immune tissues (Deleeuw et al., 2012; McInnes et al., 2012). This evidence concerns the gene FOXP3 and neoplasm.