In neuropathic Gaucher disease (nGD), subdivided into type 2 and type 3 Gaucher disease, the deficiency of glucocerebrosidase (GC) causes glucosylceramide (GluCer) and glucosylsphingosine (GluSph) to accumulate in the brain, leading to neurologic impairment. This evidence concerns the gene GC and Gaucher disease.