Using HBHA- and rESAT-6-IGRA applied to the LTBI cohort studied here, we propose that a small proportion (four out of 23, group C) cleared the infection, whereas most (roughly 50%, group A) featured a stable HBHA- and rESAT-6-IGRA profile, with a strong HBHA-specific IFN-γ response and are most likely protected from disease. Here, IFNG is linked to infection.