Since HBHA is a protective antigen [27]–[30] and since in most LTBI subjects, in addition to IFN-γ secretion, the HBHA-specific T cells also express microbicidal and cytotoxic activities to mycobacteria-infected cells [31], we suggest that this group of LTBI subjects might be protected against TB re-activation and, unless undergoing immunosuppressive treatments, does not require IPT. Here, IFNG is linked to tuberculosis.