Interestingly, none of the tumors from the multi tumor TMA (endometrium carcinoma, esophagus SCC, hepatocellular carcinoma (HCC), glioblastoma multiforme (GBM), GIST, pancreas adenocarcinoma, adenoidcystic carcinoma of the salivary gland) with Ano1 protein expression showed amplification of the 11q13 locus (Table S1A). Here, ANO1 is linked to hepatocellular carcinoma.