In this study, using Illumina Human NS-12 BeadChips containing approximately 12,000 nonsynonymous coding SNPs to perform an integrated genome-wide screening of DNA copy number and gene expression, we pinpointed four genes – CENPF, GMNN, CDK13 and FAM82B – that were amplified and overexpressed in both HCC and colorectal cancer. Here, RMDN1 is linked to hepatocellular carcinoma.