Tcal/Tcal and Galnt3-deficient male mice had infertility, and it is important to note that recent studies indicate that this is not due to the hyperphosphataemia, as normalizing the serum phosphate concentrations in Galnt3-deficient mice, by use of a low phosphate diet failed to correct the infertility [39]. Here, GALNT3 is linked to hyperphosphatemia.