Overexpression of survivin gene was found in a wide variety of tumor and transformed cells, including liver cancer [32]–[34] and cells in chronic HBV infected livers that are deemed close to transformation to tumor cells [32], [35], suggesting that miR-338-3p may play an important role in liver cancer formation due to its location in the fragile site locus associated with liver cancer tumorigenesis. This evidence concerns the gene BIRC5 and neoplasm.