In addition to well-documented effects of sunitinib in inhibiting tumor angiogenesis [6], [7], [36], [37], our work demonstrates that sunitinib exhibits a strong pro-apoptotic activity in colon cancer cells via PUMA induction through transcription factor FoxO3a, but not p53, NF-κB p65 or p53 homologue p73 and p63. This evidence concerns the gene FOXO3 and colonic neoplasm.