Hepatocyte growth factor (HGF, mature form of pro-HGF) is a molecule that not only has been shown to play a role in embryonic development, migration, morphogenesis, regeneration, cell survival in various tissues, and diseases including cancer, but has also been recently shown to govern hepatic glucose metabolism through an HGF-cMet-Insulin receptor hybrid [62], [63]. Here, INSR is linked to cancer.