ERBB2 and cardiac hypertrophy: We suggest that ErbB2 is a major regulator of ErbB receptors family and its downstream signaling [Figure 10], and it is possible that ErbB2 controls a subset of proteins that drive cardiac hypertrophy either through receptor signaling or through ErbB2 effects in the nucleus, where ErbB2 translocates in cleaved [50] or intact [51] forms and has been linked to the trans-activation of the COX-2 promoter [51].