As demyelination is one of the major histopathologic hallmarks in EAE and MS, histological observation indicate that the spinal cords from the immunized group without Que treatment were weakly stained with MBP and LFB, especially in the white matter tracts (arrows, Fig. 2A, B), while a more intense expression of MBP and LFB staining were observed in the Que treatment group but less intense than unimmunized group or control (Fig. 2A, B) on 30 days after immunization. The gene discussed is MBP; the disease is myeloid sarcoma.