Given that the differentiation block of OPCs as a cause for failure of remyelination in chronic MS [20], our data suggests that the therapeutic effect of Que on EAE may be due to, at least in part, the capacity to promote OPCs differentiation into mature OLs that enhances remyelination in EAE model, similar to certain growth factors such as insulin-like growth factor 1 (IGF-1) or T3 [21], [22] which have been shown to promote remyelination efficiency in EAE even the precise molecular mechanisms remain unclear. Here, IGF1 is linked to myeloid sarcoma.