The double labeling experiments with CC1/MBP and CD4 showed CD4+ cells were abundantly distributed in the white matter upon EAE induction (Fig. 5A,C, arrowhead), and were specifically localized to demyelination lesions (Fig. 5A), while CC1+ OLs were absent from these areas (Fig. 5C). Here, CD4 is linked to Peripheral demyelination.