However, when we injected the antiepileptic drug, Phenytoin (30 mg/kg), intraperitoneally one hour prior to the ischemic surgery in a separate cohort of APP−/− mice (n = 13 saline injected and 12 phenytoin injected), we did not find that this drug paradigm had an effect on ischemia-related mortality. Here, APP is linked to ischemia.