We then repeated the experiment (Figure 1C) and found that the colorectal cancer cell with the MOCK control (SW620-MOCK) cells maintained mesenchymal cell morphology with spindle and fibroblastoid shape cells, while the cells with SOX2 knock down (SW620-shRNA-SOX2) showed epithelial cell morphology with epithelioid spreading cells (Figure 1D). Here, SOX2 is linked to colorectal cancer.