However, we found that SOX2 staining correlated with advanced T3–T4 tumor stages, which are defined by tumor invasion through the muscularis propria into the pericolorectal tissues (T3) or by tumor penetration to the surface of the visceral peritoneum or to other organs or structures (T4) (T1–T2 tumors vs. T3–T4 tumors, P = 0.0006, Chi-square test using log likelihood ratio) (Figure 6G). This evidence concerns the gene SOX2 and neoplasm.