As shown in Fig. 2 and Fig. S1, HO-1 was upregulated in 3/3 melanoma cell lines (WM1158, WM983-B, and WM852); TACO-1 was downregulated in WM1158 melanoma cells and not detectable in two melanoma cell lines (Lu1205 and WM983-B) (data not shown); and HIF-1α was upregulated in 3/3 melanoma cell lines (WM1158, WM983-B, TPF10-741). This evidence concerns the gene TACO1 and melanoma.