HO-1, because of the high number of tryptic peptides identified by the mass spectrometry analysis; TACO-1 because it was the most significantly suppressed protein in Elesclomol-treated melanoma cells (approximately 30-fold); and HIF-1α because the IPA-Tox analysis identified the HIF-1α pathway as one of the most dysregulated pathways following Elesclomol treatment (Table 2). Here, HIF1A is linked to melanoma.