In 2005, a second case of a STAT5b deficiency was identified in a 16-year-old Turkish female with severe growth failure, GHI, atopic dermatitis, pruritic skin lesions, primary idiopathic pulmonary fibrosis with diffuse lung involvement, and autoimmune disease, as well as bleeding diathesis caused by defective thrombocyte aggregation, preventing a potential lung biopsy (Hwa et al., 2005). This evidence concerns the gene STAT5B and autoimmune disease.