FGFR2 and Dent disease: Genetic diseases linked to Alu integration events include neurofibromatosis via an insertion in the NF1 gene (Wallace et al., 1991; Wimmer et al., 2011); Apert syndrome, a severe autosomal dominant disorder, due to integration of the element into the fibroblast growth-factor receptor 2 (FGFR2) gene (Oldridge et al., 1999); and progressive renal failure (Dent's disease) due to disruption of the renal chloride channel (CLCN5) gene (Claverie-Martin et al., 2005).