IL10 and amyotrophic lateral sclerosis: It is therefore possible to hypothesize that the reduction of T-reg cells in the blood of sporadic ALS patients might represent a recruitment of these cells from the periphery into the CNS in order to activate resident innate immune cells such as microglia, as well as anti-inflammatory cytokines such as interleukin-10 and transforming growth factor-β in an effort to protect the area most affected by the early effects of ALS degeneration (Kipnis et al., 2004; Mantovani et al., 2009).