Evidence suggests that EAAT2 is significantly decreased in the motor cortex and spinal cords of ALS patients (Fray et al., 1998), as well as in the spinal cords of mSOD1 transgenic mice (Bruijn et al., 1997) and rats (Howland et al., 2002). The gene discussed is SLC1A2; the disease is amyotrophic lateral sclerosis.