Adjusting for gender, age, HIV exposure group, AIDS diagnosis prior to baseline, non-AIDS event prior to baseline, hepatitis B and C status, hypertension, anaemia, baseline CD4 count, baseline date and baseline on cART/viral load status accounted for some of the higher rate of AIDS-related mortality observed in East Europe, though the rate of AIDS-related mortality was still more than double the rate in South Europe (IRR 2.27, 95%CI 1.42–3.46, p = 0.0006). This evidence concerns the gene CD4 and hepatitis B virus infection.