Given that levels of sIL-6R correlate with positive symptoms in schizophrenia and that sIL-6R can (regulate/modulate) IL-6 activity, it is noteworthy that administration of IL-6 to rodents induces behavioral changes, with single injections of IL-6 stimulating ambulatory exploration in Balb/c mice [18] and repeated injections increasing locomotion and emotional behaviors in rats [19]. Here, IL6R is linked to schizophrenia.