LINGO1 and essential thrombocythemia: While a genome-wide association study (GWAS) [27] found a strong statistical association between Leucine rich repeat and Ig domain containing Nogo receptor interacting protein-1 gene (LINGO1) rs9652490 and rs11856808 SNPs and the risk for developing ET in an Icelandic population, the results of further studies were controversial, and the results of a metaanalysis showed no association of the rs9652490G allele, and a weak association of the rs11856808T allele with the risk for ET, although both variants showed a weak association with the risk for developing familial ET [28].