HSPA5 and neoplasm: The association of high expression levels of GRP78, GRP94 and HSP60 in tumours with a more aggressive clinical behaviour might lead to new therapy strategies, as therapeutic agents that inhibit HSPs and GRPs have been developed in recent years and have already been shown to act as powerful anti-tumour agents both alone and in combination with conventional chemo- or radiochemotherapy [10]–[12], [14], [39]–[41].