In order to comprehensively elucidate the role and the regulation of HSPs and GRPs in oesophageal adenocarcinomas, we studied the expression of HSP27, phosphorylated (p)-HSP27(Ser15), p-HSP27(Ser78), p-HSP27(Ser82), HSP60, HSP70, HSP90, GRP78 and GRP94 in a well-characterized, homogenously treated collection of patients with primary resected oesophageal adenocarcinomas. Here, HSPA5 is linked to esophageal adenocarcinoma.