HSPA5 and neoplasm: Here we show that a protein expression pattern of low p-HSP27(Ser15, Ser78, Ser82) and high GRP78/GRP94/HSP60 in the tumours was significantly associated with a poorer prognosis and that this particular protein expression profile was superior to conventional pathologic prognostic factors of the UICC TNM classification system in multivariate analysis.