PIK3CA and colorectal carcinoma: To this purpose, based on the Catalogue of Somatic Mutations in Cancer (COSMIC) database (http://www.sanger.ac.uk/genetics/CGP/cosmic/) and on the study of Jhawer et al. [13], CACO-2, SW48, HT-29, Colo205, SW480, SW620, RKO, LS174T and HCT-116 CRC cells were chosen (see Table 1 for their corresponding KRAS, BRAF and PIK3CA status).