We then transferred spleen cells obtained from HLA-DR4+/hCD4+ mice (which contained ∼2×104 Mam-A specific CD4 T cells, determined by intracellular IFN-γ staining, Fig S4) along with spleen cells from HLA-A2+ transgenic mice vaccinated with Mam-A2.4 DNA into SCID-beige tumor bearing mice and examined tumor growth (Fig. 5g). This evidence concerns the gene IFNG and neoplasm.