BDNF and leiomyosarcoma: Although SKN is derived from a uterine leiomyosarcoma distinct from that which gave rise to the MES-SA and MES-SA/Dx5 cells [37], its proliferation was also suppressed by inhibiting TrkB signaling (Fig. S2B), suggesting important endogenous roles of BDNF/TrkB signaling in growth of leiomyosarcoma cells.