In another recent study involving 4585 consecutive patients who were found to have malignant or indeterminate thyroid nodules by ultrasonography, BRAF(V600E) mutation analysis using three independent molecular assays in FNA cytology specimens did not show any significant correlation with multifocality, extrathyroidal extension, and lymph node metastasis [27]. The gene discussed is BRAF; the disease is metastatic malignant neoplasm in the lymph nodes.