DRB1*15 is one of the susceptibility factors for multiple sclerosis [52] and DRB1*15 alleles is associated with significantly increased risk to develop hepatocellular carcinoma in Asians (OR = 2.88, 95%CI: 1.77–4.69, P<0.001) [53]. This evidence concerns the gene HLA-DRB1 and multiple sclerosis.