The X-linked Duchenne and Becker muscular dystrophies (DMD and BMD) are caused by mutations in dystrophin (Dys) associated with muscle plasma membrane fragility, increased intracellular Ca2+ levels and proteolytic activity [1], [2] leading to muscle myofibrillar decomposition with subsequent replacement by fibrous and fat tissue. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.