In particular, hNPCPSA-NCAM+ derived from PD-iPSC4 spontaneously differentiated into Tuj1/NeuN-double positive neuronal cells, O4-positive oligodendrocyte precursors, and GFAP-positive astrocytes under differentiation conditions (Fig. 5F–H). The gene discussed is IGKV1D-37; the disease is Parkinson disease.