For sepsis prognosis, the areas under the ROC curves for initial sCD163 and PCT levels and SOFA scores were, respectively, 0.706 (95%CI: 0.604–0.808), 0.669 (0.551–0.786), and 0.758 (0.695–0.875), which showed that sCD163 levels and SOFA scores exhibited moderate performance for determining sepsis prognosis. The gene discussed is CD163; the disease is Sepsis.