For the diagnosis of severe sepsis, the areas under the ROC curves for the initial sCD163, CRP, and PCT levels and SOFA scores were, respectively, 0.811 (95% CI: 0.723–0.899), 0.633 (0.522–0.744), 0.6477 (0.522–0.774), and 0.701 (0.599–0.802); The optimal cut off point was estimated to be about 2.11 ug/mL, at which the sensitivity and specificity of the test would be 77.2% and 79.1% this showed the that sCD163 was better than PCT, CRP, and SOFA scores for the diagnosis of severe sepsis. The gene discussed is CRP; the disease is Sepsis.