The group with obesity and overweight had a negative correlation between adiponectin and VEGF concentrations (r = -0.34; P = 0.04), a positive correlation between VEGF concentration and fat mass (r = 0.39; P = 0.02), and a negative correlation between adiponectin concentration and fat mass (r = - 0.23; P = 0.02). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.