Currently available evidences show that IL-27 promotes the inflammation in diseases such as experimental crescentic glomerulonephritis [33], experimental hepatitis [34] and colitis [35], systemic sclerosis [36]; but suppresses the inflammation in diseases such as autoimmune arthritis [37], allergic asthma [38, 39], chronic inflammation of the central nervous system [29], experimental autoimmune encephalomyelitis [40–42], intraocular inflammation [43], Leishmania donovani infection [44]. The gene discussed is IL27; the disease is colitis.